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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

adj. 最初的,原始的,有独创性的,原版的
Denmark, for instance, is 88 percent white Danish today — hardly a majority in jeopardy. But a generation ago, in 1980, it was 97 percent white. The anti-immigrant Danish People’s Party is now the second-largest party in the Danish Parliament. In Germany, where the foreign-born population shot up by approximately 75 percent between 2011 and 2015, the anti-immigrant, populist Alternative for Germany party is now drawing record support.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

大多数汇款出自美国(1170亿美元)、欧洲(1150亿美元)和海湾国家(1000亿美元)。
Apple (AAPL, Fortune 500) announced that it would put $30 billion of its cash toward share repurchases. The news made investors happy: The stock popped, and even a week later was up 12% relative to the S&P over that same 7-day period. The buybacks were part of a larger $130 billion capital return program that the company said would extend through 2015.

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

From the themed collection: 水泥前十企业2015年集中度达45%
Open Access Perspective

Soft matter science and the COVID-19 pandemic

中国的各个创新指标显现出“持续稳健的进步”,高锐表示,“没有理由认为这前进的脚步会停下来。”

Graphical abstract: Soft matter science and the COVID-19 pandemic
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

37岁的吉赛尔·邦辰赚得1750万美元,排名第二,自2002年以来这是她第一次没有登顶模特收入榜单。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
From the themed collection: 告别高增长时代厨电业走向何方?
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

The One-China policy constitutes the political foundation of China-US relations which has remained unshaken despite the changing circumstances, nor can this relationship be undermined. With that foundation in place, we believe that there are broad prospects for China-US cooperation.
普华永道的校园和学校雇佣主管安德鲁?巴杰里(Andrew Bargery)表示,Teach First的毕业生出类拔萃:“他们已经在专业环境下工作过,拥有专业成熟度,并擅长交际。”
n. 运输,运输系统,运输工具
[s?'plai]

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
From the themed collection: 下一轮调控重点须从房价转向地价
Perspective

Trends and targets in antiviral phototherapy

据Birinyi Associates的数据,今年迄今为止,各家公司已经宣布了376项股票回购计划,总额高达2,610亿美元。这个数字与2012年相比增长了近72%,但与回购创下纪录的2013年相比,略微有所回落。
社交网络平台,包括微博和手机应用微信,被证明是网红扩大交流的最好工具,使其可以创造出一种囊括广告、电子商务和粉丝的行业。
7.管理多向性
3.You Spend More Time Surfing the Web Than Doing Your Job

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

Cannes' heckles and jeers are famous and the first film to fall foul of this tough crowd was Gus Van Sant's Sea of Trees, which was greeted by a storm of raspberries and thunderous boos at its press screening. Because these take place before a film receives its black-tie premiere, word quickly gets around and can cast a pall over the big event. When Naomi Watts and Matthew McConaughey took their turn on the red carpet, it had “a horrifically compelling walk-of-shame quality” according to the Daily Telegraph. But the Texan actor put on a brave face at a press conference shortly afterwards. “Anyone has as much right to boo as they do to ovate,” he said. I think we know what he meant.

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

如果一部情景喜剧播出10年堪称流行,那么播出20年后依旧令无数人挂怀的电视剧则是经典。《老友记》1994年在美国首播,讲述了六个生活在纽约的青年男女的故事。现在,该剧已经是最著名的情景喜剧之一,在全球超过100多个国家和地区播出。

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
From the themed collection: 盘点2015年陶卫企业倒闭事件
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

昨日,中国四大国有银行中的两家——中国工商银行(ICBC)和中国银行(BoC)——均报告称,2015年全年净利润增长低于2%。
Lawrence, 26, took the top spot largely through a slice of the profits from the final movie in the Hunger Games franchise, as well as a big upfront fee for her forthcoming space adventure movie Passengers, Forbes said.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

Every great detective needs his or her definitive story. For Sherlock Holmes it was The Hound of the Baskervilles. For Agatha Christie’s fussy Belgian sleuth Hercule Poirot it’s Murder on the Orient Express – a tale in which a bloodthirsty villain kills a wealthy businessman during a train journey through the Balkans. Or are things really what they seem? Sidney Lumet made a beloved film out of the story in 1974, with a stunning cast that included Sean Connery, Ingrid Bergman and Albert Finney as Poirot. Now Kenneth Branagh is donning the Belgian’s moustache himself, as well as stepping behind the camera as director, in his glossy new big-screen version, starring Johnny Depp, Daisy Ridley, Michelle Pfeiffer, Penelope Cruz and Dame Judi Dench. Is there something new that can be mined from this story? Maybe. But even if not, Christie fans will surely want to climb aboard. Released November 3 in the UK, November 10 in the US, China and Turkey, and November 30 in China's Hong Kong and Singapore. (Credit: 20th Century Fox)
对胎儿进行手术有可能改变他们的人生。

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
From the themed collection: 家居行业未来更加成熟
Open Access Review Article

Diagnostic technologies for COVID-19: a review

如果你需要买一辆新车,你有36个可选择的品牌。每个汽车品牌都满足了不同的需求,但并不是每个品牌都适合每一位消费者。有些品牌擅长制作高性能的车,有些专注于制作家庭适用的跨界休旅车,或是专门制作豪华型轿车。
由于净利润增长缓慢,我国16家上市银行削减了去年的分红。

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

TextPride已经改名为Swyft Media,并推出了一个能将新品牌表情符号和贴纸推送到短信应用中的新平台。各大品牌需要为此付费,一如传统的广告推广活动。
Recipient: Their Royal Highnesses The Duke and Duchess of Cambridge (joint winners)
1Switzerland
现在的假手除了具备手的外形外,几乎没有其他功能。当然,这些假手能够拿东西和保持身体平衡,但是它们缺乏人手最重要的功能之一——触感。装了假手的人在碰触到一样物品时,如果不用眼睛看,是没法判断东西的。

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
From the themed collection: 长三角,一体化升级“加速跑”
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

为了让世界都关注濒危物种和中国成都大熊猫基地,演出者们全力表演,节目精彩令人难以忘怀。他们不仅给伦敦市民带去了乐趣,还与基地大使、自然主义者奈杰尔-马文一同去学校向孩子们宣扬熊猫保护的理念。

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

这是自从2011年以来谷歌首次荣登榜首。
当支持者在周一早些时候涌向总督大楼,一人高喊,"今天,新的波多黎各开始了!" 随着其他人的欢呼,包括那些拿着美国国旗的群众。

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

乔布斯正在展示 iPad 2。2011年3月,旧金山

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

8.Show Appreciation

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

complex
2.人工眼睛
“为了让世界更好,我想到了一台革命性的净水器” 谷歌引用了张天羽的原话,“它能够大量转化江河湖海里的污水,把它们变成安全卫生的净水。人和动物喝这种水,会活得更健康。”
GDP growth of around 6.5 percent, or higher if possible in practice.

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
From the themed collection: 未来已来,新工具赋能城市新时代
Review Article

Influenza neuraminidase: A druggable target for natural products

韩国全州——在全州的韩屋村,仍保留着几百座传统的韩式房屋。
An odd assortment of S&P sectors led the market higher this year, with some strange bedfellows atop the leaderboard. Even if a manager had foreseen that the healthcare sector would gain 27% this year, would they have guessed that utilities would be in the No. 2 slot, with gains of 23%? Unlikely.
纽约的一家餐馆正在尝试制作市面上最“腐败”的披萨,这种披萨表面覆盖了黄金薄片、鹅肝和松露。
全面提升质量水平。
1.Nepal

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

凯特哈德森接受ELLE专访谈感情
在上周二晚上放学后,孙轶潇乘坐电梯回家,可是电梯突然故障停止运行。

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

I am here to speak on behalf of the starving children around the world whose cries go unheard. 我演讲是为了世界所有忍受饥饿的儿童,而他们的哭泣却无人听见。

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

We need to ensure that our consumers will have access to good options, benefit from such consumption, and most importantly that Chinese companies will be able to win over the consumers with their commitment to high quality and workmanship.

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

The Producer Price Index (PPI), which gauges factory-gate prices and is a major indicator of economic briskness, rose by 6.3% in 2017, compared with a minus 1.4% for 2016, reversing the trend of continual decline since 2012.
《中国文化遗迹》杂志是一本新创立的期刊,专门把发表在《文物》杂志上的原创文章翻译成英文。其创刊号上就发表了这座1700年墓地的发现。
adj. 国内的,家庭的,驯养的
I mean, is it worth to be a No. 8 seed with Serge Ibaka and Jeff Green leading the way? Maybe it is. This all just seems awfully backwards.

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

Inflation (and deflation) won't rear its ugly head Surging oil production — along with slower global growth — has caused the price of petroleum to collapse from more than $100 a barrel last summer to barely $50 a barrel at the end of 2014. The effect has been to reverse an uptick in U.S. inflation earlier in the year.
Blige will perform "Mighty River" from "Mudbound," the Oscar-nominated song she co-wrote with Raphael Saadiq and Taura Stinson. Blige is also nominated for best supporting actress for her role in "Mudbound." She is the first person to be nominated for both a performance and an original song in the same year.
积极稳妥去杠杆。
尽管欧洲工商管理学院与清华大学的合办项目重新跌至亚军位置,但欧洲工商管理学院自己的EMBA项目的排名却上升3个位置,排在第四位,该项目上次获得第4名是在2011年。

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

Faber laughs at Bernanke's remark that the economy would be strong enough later this year so he could take his foot off the gas, that is begin 'tapering, or scaling back it's stimulative quantitative easing (QE) program later this year.' Yes, laughed.
Female founders in Silicon Valley will raise more money next year, as sexual harassment scandals have forced investors to rethink their habit of backing ventures founded by mainly young, white men. Some start-ups founded by men pursued by rumours of unsavoury pasts will not get funding, even if they are a good investment proposition.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

adj. 民主的,大众的,平等的
当地媒体上周三报道,中国西南部重庆市的一名学生因嫌同学上课吵闹而试图下毒,被判有期徒刑一年。
The block chain has such rich potential that there is an initiative underway to create additional “side chains,” though there is controversy around that idea. “We don’t really want to mess with the main block chain right now,” says Adam Ludwin, CEO of Chain, a block chain API that makes it easier to create bitcoin applications. “It works, we don’t want to break it.”
赖床有了新理由
The Lost Tomb

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

A member of staff at the Yizheng Museum told MailOnline that the bronze item had been found inside the tomb of an aristocrat in the West Han Dynasty (206 BC–8 AD) the first part of the Han Dynasty.
国有企业员工对年终奖表达了比民营企业更高的满意度。这一点毫不奇怪,因为国企的平均年终奖是17318元人民币,比民企的预期年终奖高了大约6000元人民币。
《伯德小姐》

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

单词temporary 联想记忆:
While Insead’s joint programme dropped back into second place, its single-school programme moved up three places to fourth, a place it last occupied in 2011.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

《在生前留下的物品中回忆世界上最长寿的人》(Remembering the World’s Oldest Person, in the Objects She Left Behind)
US president Donald Trump’s zero-sum, Art-of-the-Deal approach to negotiation will give comfort to old-fashioned incumbents. I am hoping 2018 will provide an opportunity for positive, problem-solving new leaders to emerge. But change could stall if business chiefs, disheartened by the poor quality of political leadership, turn inwards instead.
Wang Dengfeng, director of the Physical Education, Health and Art Department under the Ministry of Education (MOE) and Vice Chairman of the China Football Association, was quoted as saying that football experts are designing curriculums for more than 360 training programs in primary and secondary schools.

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

迅速崛起的“色情短信”服务商Snapchat与早期的社交媒体巨头Facebook具有令人不可思议的相似性。我们现在都知道扎克伯格早早就投下的赌注获得了多大的成功(更不必说他还彻底击败了卑劣的文克莱沃斯孪生兄弟)。那么,Snapchat能否拥有同样光明的未来?
For: The Los Angeles Critics Association gave it their top prize.
The Harvard article suggests that protecting the brain with a heart-healthy diet could be the key to warding off dementia and keeping your memory intact well into your golden years. Some studies have suggested certain foods have a positive impact on memory, but no study thus far has revealed the existence of a miracle food. The idea that a heart-healthy diet could also prove beneficial to the brain and memory has become popular with doctors studying Alzheimer's disease and dementia. Some of the risk factors associated with heart disease are similar to those associated with dementia and Alzheimer's. Foods recommended for a heart-healthy diet include fruits, vegetables, and whole-grain bread, as well as beans, nuts, and olive oil. If you can't use every one of these 10 scientific secrets to a perfect memory, a healthy diet might help you avoid losing it!

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

consult

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

虽然也有各种各样的政策鼓励,但许多会采取减免税务、低息贷款或退税的形式。因此,楼盘运营方或许将不得不从估价中征税,或增加维护费,以此打平楼盘运营的初始成本。“你会遇到没人为你提供前期资金的问题,”卢森堡说。

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

vt. 监禁,下狱
Although Chinese domestic suppliers have expanded their market share to 32.7% in 2016, the trend was reversed in 2017, as their share shrank to 26.8%, said Qu Daokui, president of China Robot Industry Alliance.

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

输家:尼克斯
8. It’s never too late to start.
“我想,在21世纪,人们绝对会质疑这件事。”
vi. & vt

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
From the themed collection: 从“囤房”到“以房养老”有多远
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

举例来说,新浪微博就一直提供推特所不具备的一些功能,尤其是评论功能,让众多用户得以在别人发表的微博下发表自己的见解。拥有逾7亿用户的腾讯QQ即时信息服务也有众多附加功能,比如可以让用户改换形象的“皮肤”,同时QQ还是腾讯为其他产品和服务做广告的渠道。新浪拒绝置评。
最终,民主政体或者民主共和国为不同观点乃至不同文化的人们提供了较为和谐地比邻而居的方式。

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

时隔多年,贝尔蒙特如今已是一位白发苍苍的老人。没能现场观看1950年世界杯的决赛,他从不感到后悔。那次决赛过后没几天,他的母亲就去世了。“我当时决定放弃观看比赛的机会,事实证明这样做是正确的。”他对记者说。
Some of them still give high return to their shareholders. China Merchants Bank is generous; its dividend reached 30.16% of its net profits.

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

And, men are 2.8 times more likely to use this obvious phrase than women.

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

3.数学家
China is the most striking wild card that will drive agricultural markets, said Stefan Vogel, head of agri commodity markets at Rabobank,
However, respondents also noted that social media has caused them to read fewer books, suffer from worse eyesight, sleep less and maintain less privacy, among other concerns.
Exports to the EU, Japan and Hong Kong — which serves as a transit point for exports to many other parts of the world — fell by 4.1 per cent, 9.5 per cent and 12.2 per cent respectively.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

DOWNTON ABBEY (PBS, Sunday) Season 5 begins with new blows to Lord Grantham’s self-esteem and the somewhat Victorian touch of an illegitimate baby hidden away in a cottage. For those who haven’t already pirated the British broadcasts or read the recaps, let’s just say that the first episode involves a very heated situation.
add增加,ition名词后缀

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

[k?n'vi:nj?nt]
survival
《权力的游戏》不仅是秋季剧中下载次数最多的美剧,还是全年美剧下载之王。数据统计,使用非法下载方式来观看这部剧的人比用电视看的人还要多得多。

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

二月的一天,苹果(Apple)的年度股东大会进行了一个多小时,蒂姆?库克(Tim Cook)已经耐心地回答了苹果进军电视市场的计划和他如何看待谷歌眼镜(Google Glass)等各类问题。但当一位参会听众就苹果各环保项目(比如其太阳能数据中心)的盈利能力向这位首席执行官发难的时候,库克发怒了。
So too would be concluding the EU’s own (re)negotiation of its existing trade agreement with Mexico. And there is a good chance Brussels could beat Donald Trump to the finish line on a deal with Mexico.
分析师和评论员们对石油市场的解读着重于供应端,以及沙特或其他地方的产量和出口量。供给很重要,但成本更重要。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

Total net profit for China’s commercial banks grew by 2.4 per cent last year, according to data from China’s bank regulator. Smaller banks saw increases in profit growth, while bigger banks slowed down.
“这可是短期内的大幅跃升:当我还是内政部长时仅有30个案例,今天则是1400。”

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

Time Management
Unlike most boy-band dudes going solo, he never sounds like he's sweating to get taken seriously – he never loses touch with the exuberance and swagger he brought to One Direction in the first place. So get used to this man – you'll be hearing a lot more from him.
能够再次主持奥斯卡我感到非常激动和荣幸。你知道有句老话:第三次总是幸运的。

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

The former Miss Israel, Gal Gadot spot 6th in the list of 10 most beautiful women of 2015. She is the leading fashion model for the clothing company Castro. Gadot is known for her role as Gisele Yashar in The Fast and the Furious film series.
2. You've suddenly become a Twitter thought leader。

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

判断权在你手里。
Yet for all Russia's pretence about a rebalancing of priorities towards Asia, since the fallout over Ukraine, it still measures itself against the West, and America in particular.
Fast & Furious 6 helped place two other actors high on our list: Vin Diesel and the late Paul Walker. Diesel lands in fourth place with $887 million. Fast & Furious 6 earned $789 million at the box office worldwide. The third movie in his Riddick franchise hit theaters just a few months after. It only pulled in $98 million, but that was enough to put Diesel ahead of his co-star Walker on our list.

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
From the themed collection: 告别“激进” 房企低调控风险
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

STEP 4: REMIND EVERYONE about what an "idiot" or "moron" they are

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

但最近,回购势头开始减弱。跟踪回购比例最大的100家公司的标准普尔500回购指数最近创下了自2012年年中以来的首次下跌。随着股价连创新高,股票回购所产生的推动作用消失,公司投资较长期项目或使用多余现金进行收购变得更有价值。
Succeeding as an entrepreneur takes hard work and persistence because, unfortunately, there is no business-startup fairy who magically bestows success on small businesses and their owners.

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

另一方面,10月份工业生产者出厂价格(PPI)连续第3个月同比下降5.9%。
虽然仿生腿对截肢者来说是巨大的福音,但是它们与人体缺乏真正的神经联系,导致依靠仿生腿走路十分麻烦和劳累。但是去年,西雅图的居民Zac Vawter 安装了世界上第一支思想控制的腿,一种直接接受从他大脑发出信号的仿生肢体。

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
From the themed collection: 石家庄一季度拆除17家水泥企业
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

这造成了一种有待填补的身份认同真空。
Actively expanding China's opening up to the world

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

尼泊尔的最佳旅行时间在今年的1月份到5月份。届时一定要去该国的加德满都谷底,该地区是尼泊尔的政治文化中心,同时也是世界遗产的集中地区,建筑风格多种多样,文化气息十分浓郁。此外,南部地区的奇旺国家公园也是必去之地,许多诸如印度犀牛和孟加拉虎等罕见野生动物都聚居在此地。
由于孙轶潇没带手机,他开始尝试大声呼救以引起外面人的注意,但是时间一分一秒地流过,并没有人回应他。

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

《琅琊榜》的意外爆红让这部戏成为2015年秋季档电视剧中的翘楚。同样改编自网络小说(海晏著)的《琅琊榜》2015年9月首播。该剧由胡歌、刘涛等人主演,讲诉了才冠绝伦的谋士梅长苏为昭雪多年冤案进行的一系列斗争。虚构的人物和朝代让改编剧集巧妙地躲过了历史准确性上的责难。它精美的场景布置和无懈可击的故事情节受到了广大观众的一致好评。

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

But with the US close to full employment and inflation moving up towards the target, “you can see how tighter policy would be warranted,” he says. “It wouldn’t take a whole lot to shift the equation.”
艾玛·汤普森曾因影片《霍华德庄园》(Howards End)以及《理智与情感》(Sense and Sensibility)两次获得奥斯卡金像奖,而她把小金人放在洗手间这一做法也广为人知,她说:“放在其他地方都显得格格不入,它们太大了,又金光闪闪。”而艾玛并不是唯一一个这样做的人,苏珊·萨兰登(Susan Sarandon)、莱昂纳尔·里奇(Lionel Richie)以及肖恩·康纳利(Sean Connery)都称自己把小金人放在浴室等地方。
现代中国经销商Wang Rongzhen7月20日向路透社指出,现代汽车已经缩减提供给中国进口经销商的产品阵容,仅提供一款车型供销售,而在中国国产的车型不断增加。
多达10000份影片(一个虚构CIA刺杀北韩领袖金正恩的喜剧片)和500000份宣传单将会在3月26号左右通过气球投放。

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

"He promised when he took office that he would have a Cabinet that was 50 percent women, and then he did it," Maddow said. "Would you make that same pledge?"

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
From the themed collection: 家居装修可用贝壳粉涂料吸收甲醛
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

明年,寻找新楼盘的买家将会有更多的选择。根据科克伦阳光营销集团(Corcoran Sunshine Marketing Group)提供的数据,明年(2015年——译注)曼哈顿、布鲁克林和皇后区长岛市(Long Island City)新上市的共管公寓预计将增加一倍以上,从2014年的3444套增加到8366套。
Having earned a living for the last four years while her contemporaries go to school every day, she has been forced to mature quickly.
问:你今年夏天去了美国,感觉怎样?

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
From the themed collection: 开学季来临 儿童家居市场加温
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

你没有赚到足够多的钱来支付日常开销
entertainment

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

在去年的调查中,绝大多数经济学家预期欧洲央行将发起全面量化宽松政策,而今年33个受访者中有几乎快一半的人认为欧洲央行将按兵不动。其他人表示,欧洲央行将扩大量化宽松或下调利率,尽管在那些预期会有更多宽松措施的人中,一部分人强调这家央行不太可能从根本上重塑其现有的政策回应。
It will be interesting to see which direction they go at the trade deadline. They have a handful of solid players along with Brook Lopez.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

11月18日

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

Copestake said fears over economic austerity and the stability of the euro had pushed the index of euro zone cities down in the past year while the inclusion of Caracas was due to artificially high exchange rate controls.
Auto sales: Car sales reach 17 million but manufacturers scramble to adjust capacity as trucks and SUVs soar in popularity. Pressure to hold down corporate fuel averages drives margins on small cars far below break-even.
多数天主教徒(60%)和非福音派白人新教徒(65%)表示,他们相信飓风和洪灾等自然灾害是气候变化所致。

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

2.German: 22.2 percent increase
Best Companies rank: 1
Paris is in third place with 18.03 million forecast visitors.
[sp?n'teini?s]

Graphical abstract: Length-scale dependence of protein hydration-shell density
From the themed collection: 警方打掉“套路贷”敲诈勒索团伙
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

米特卜王子被捕不到一个月即获释,这显示出沙特想要迅速结束这场腐败调查,阿尔瓦利德·本·塔拉尔王子等多名王室成员和亿万富翁在调查中突然被捕。
In a sign that civil service jobs may be losing their appeal, a report issued by recruitment website Zhaopin in late March said more than 10,000 public sector employees, including civil servants and staff members at public institutions, had submitted their resumes to potential employers through the site in just two months. The number was 34 percent higher during the same period last year, the report said.

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

在不同产业和不同城市之间,年终奖的数额也有很大不同。金融机构的平均年终奖为1.72万元人民币,而教育部门年终奖则平均不到这一数额的一半,只有不足7500元人民币。
Wheel skates look somewhat like regular inline skates, except that the wheels are much larger, up to the size of bicycle tires. They are seen as a cross between an inline skate, a ski, and a bike. Recently, a company called Chariot Skates said they had come up with something unique—the Chariot wheel skates. According to the company, wheel skates are "revolutionary new skating products." Revolutionary? They do at least revolve. New? No. The first wheel skate was made more than 142 years ago.
The reading is just below economists' forecasts but it's not altogether surprising. When the People's Bank of China unexpectedly cut interest rates last month, some analysts said the move was likely a pre-emptive one and that a spate of weak data was likely ahead. Well, here it is.

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
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厌倦了一成不变的生活?何不去探险,让身心重新焕发活力?毫无疑问,南极洲会是个好去处。亲眼目睹企鹅嬉戏,成群结队的海鸟飞过天空,要比观看电视纪录片更令人兴奋。想象一下,置身于雄伟冰山和原生态山脉构成的世界中,是多么刺激和美好的一件事啊!但要注意的是,南极洲地处极地,因此行前要做好充足准备。保暖靴、防寒外套、手套、羊毛袜和帽子一样都不能少。
On the flip side, why do so many JetBlue flights arrive late during the holidays (22 percent)? For one thing, it flies to and from some of the busiest airports in the country, including New York’s JFK, LaGuardia and Newark Airports. And it encounters some of the same issues as Hawaiian does over the Pacific.

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