Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Denmark, for instance, is 88 percent white Danish today — hardly a majority in jeopardy. But a generation ago, in 1980, it was 97 percent white. The anti-immigrant Danish People’s Party is now the second-largest party in the Danish Parliament. In Germany, where the foreign-born population shot up by approximately 75 percent between 2011 and 2015, the anti-immigrant, populist Alternative for Germany party is now drawing record support.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Apple (AAPL, Fortune 500) announced that it would put $30 billion of its cash toward share repurchases. The news made investors happy: The stock popped, and even a week later was up 12% relative to the S&P over that same 7-day period. The buybacks were part of a larger $130 billion capital return program that the company said would extend through 2015.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
The One-China policy constitutes the political foundation of China-US relations which has remained unshaken despite the changing circumstances, nor can this relationship be undermined. With that foundation in place, we believe that there are broad prospects for China-US cooperation.
普华永道的校园和学校雇佣主管安德鲁?巴杰里(Andrew Bargery)表示，Teach First的毕业生出类拔萃：“他们已经在专业环境下工作过，拥有专业成熟度，并擅长交际。”
Trends and targets in antiviral phototherapy
3.You Spend More Time Surfing the Web Than Doing Your Job
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Cannes' heckles and jeers are famous and the first film to fall foul of this tough crowd was Gus Van Sant's Sea of Trees, which was greeted by a storm of raspberries and thunderous boos at its press screening. Because these take place before a film receives its black-tie premiere, word quickly gets around and can cast a pall over the big event. When Naomi Watts and Matthew McConaughey took their turn on the red carpet, it had “a horrifically compelling walk-of-shame quality” according to the Daily Telegraph. But the Texan actor put on a brave face at a press conference shortly afterwards. “Anyone has as much right to boo as they do to ovate,” he said. I think we know what he meant.
Novel biosensing methodologies for ultrasensitive detection of viruses
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Lawrence, 26, took the top spot largely through a slice of the profits from the final movie in the Hunger Games franchise, as well as a big upfront fee for her forthcoming space adventure movie Passengers, Forbes said.
ACE2 as a potential therapeutic target for pandemic COVID-19
Every great detective needs his or her definitive story. For Sherlock Holmes it was The Hound of the Baskervilles. For Agatha Christie’s fussy Belgian sleuth Hercule Poirot it’s Murder on the Orient Express – a tale in which a bloodthirsty villain kills a wealthy businessman during a train journey through the Balkans. Or are things really what they seem? Sidney Lumet made a beloved film out of the story in 1974, with a stunning cast that included Sean Connery, Ingrid Bergman and Albert Finney as Poirot. Now Kenneth Branagh is donning the Belgian’s moustache himself, as well as stepping behind the camera as director, in his glossy new big-screen version, starring Johnny Depp, Daisy Ridley, Michelle Pfeiffer, Penelope Cruz and Dame Judi Dench. Is there something new that can be mined from this story? Maybe. But even if not, Christie fans will surely want to climb aboard. Released November 3 in the UK, November 10 in the US, China and Turkey, and November 30 in China's Hong Kong and Singapore. (Credit: 20th Century Fox)
Diagnostic technologies for COVID-19: a review
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Recipient: Their Royal Highnesses The Duke and Duchess of Cambridge (joint winners)
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
乔布斯正在展示 iPad 2。2011年3月，旧金山
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Antiviral drug discovery: broad-spectrum drugs from nature
GDP growth of around 6.5 percent, or higher if possible in practice.
Influenza neuraminidase: A druggable target for natural products
An odd assortment of S&P sectors led the market higher this year, with some strange bedfellows atop the leaderboard. Even if a manager had foreseen that the healthcare sector would gain 27% this year, would they have guessed that utilities would be in the No. 2 slot, with gains of 23%? Unlikely.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
I am here to speak on behalf of the starving children around the world whose cries go unheard. 我演讲是为了世界所有忍受饥饿的儿童，而他们的哭泣却无人听见。
Quantitative determination of mechanical stability in the novel coronavirus spike protein
We need to ensure that our consumers will have access to good options, benefit from such consumption, and most importantly that Chinese companies will be able to win over the consumers with their commitment to high quality and workmanship.
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
The Producer Price Index (PPI), which gauges factory-gate prices and is a major indicator of economic briskness, rose by 6.3% in 2017, compared with a minus 1.4% for 2016, reversing the trend of continual decline since 2012.
I mean, is it worth to be a No. 8 seed with Serge Ibaka and Jeff Green leading the way? Maybe it is. This all just seems awfully backwards.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Inflation (and deflation) won't rear its ugly head Surging oil production — along with slower global growth — has caused the price of petroleum to collapse from more than $100 a barrel last summer to barely $50 a barrel at the end of 2014. The effect has been to reverse an uptick in U.S. inflation earlier in the year.
Blige will perform "Mighty River" from "Mudbound," the Oscar-nominated song she co-wrote with Raphael Saadiq and Taura Stinson. Blige is also nominated for best supporting actress for her role in "Mudbound." She is the first person to be nominated for both a performance and an original song in the same year.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Faber laughs at Bernanke's remark that the economy would be strong enough later this year so he could take his foot off the gas, that is begin 'tapering, or scaling back it's stimulative quantitative easing (QE) program later this year.' Yes, laughed.
Female founders in Silicon Valley will raise more money next year, as sexual harassment scandals have forced investors to rethink their habit of backing ventures founded by mainly young, white men. Some start-ups founded by men pursued by rumours of unsavoury pasts will not get funding, even if they are a good investment proposition.
Inhibition of SARS coronavirus helicase by bismuth complexes
The block chain has such rich potential that there is an initiative underway to create additional “side chains,” though there is controversy around that idea. “We don’t really want to mess with the main block chain right now,” says Adam Ludwin, CEO of Chain, a block chain API that makes it easier to create bitcoin applications. “It works, we don’t want to break it.”
The Lost Tomb
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
A member of staff at the Yizheng Museum told MailOnline that the bronze item had been found inside the tomb of an aristocrat in the West Han Dynasty (206 BC–8 AD) the first part of the Han Dynasty.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
While Insead’s joint programme dropped back into second place, its single-school programme moved up three places to fourth, a place it last occupied in 2011.
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
《在生前留下的物品中回忆世界上最长寿的人》(Remembering the World’s Oldest Person, in the Objects She Left Behind)
US president Donald Trump’s zero-sum, Art-of-the-Deal approach to negotiation will give comfort to old-fashioned incumbents. I am hoping 2018 will provide an opportunity for positive, problem-solving new leaders to emerge. But change could stall if business chiefs, disheartened by the poor quality of political leadership, turn inwards instead.
Wang Dengfeng, director of the Physical Education, Health and Art Department under the Ministry of Education (MOE) and Vice Chairman of the China Football Association, was quoted as saying that football experts are designing curriculums for more than 360 training programs in primary and secondary schools.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
For: The Los Angeles Critics Association gave it their top prize.
The Harvard article suggests that protecting the brain with a heart-healthy diet could be the key to warding off dementia and keeping your memory intact well into your golden years. Some studies have suggested certain foods have a positive impact on memory, but no study thus far has revealed the existence of a miracle food. The idea that a heart-healthy diet could also prove beneficial to the brain and memory has become popular with doctors studying Alzheimer's disease and dementia. Some of the risk factors associated with heart disease are similar to those associated with dementia and Alzheimer's. Foods recommended for a heart-healthy diet include fruits, vegetables, and whole-grain bread, as well as beans, nuts, and olive oil. If you can't use every one of these 10 scientific secrets to a perfect memory, a healthy diet might help you avoid losing it!
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
Although Chinese domestic suppliers have expanded their market share to 32.7% in 2016, the trend was reversed in 2017, as their share shrank to 26.8%, said Qu Daokui, president of China Robot Industry Alliance.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
8. It’s never too late to start.
vi. & vt
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Some of them still give high return to their shareholders. China Merchants Bank is generous; its dividend reached 30.16% of its net profits.
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
And, men are 2.8 times more likely to use this obvious phrase than women.
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
China is the most striking wild card that will drive agricultural markets, said Stefan Vogel, head of agri commodity markets at Rabobank,
However, respondents also noted that social media has caused them to read fewer books, suffer from worse eyesight, sleep less and maintain less privacy, among other concerns.
Exports to the EU, Japan and Hong Kong — which serves as a transit point for exports to many other parts of the world — fell by 4.1 per cent, 9.5 per cent and 12.2 per cent respectively.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
DOWNTON ABBEY (PBS, Sunday) Season 5 begins with new blows to Lord Grantham’s self-esteem and the somewhat Victorian touch of an illegitimate baby hidden away in a cottage. For those who haven’t already pirated the British broadcasts or read the recaps, let’s just say that the first episode involves a very heated situation.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
二月的一天，苹果(Apple)的年度股东大会进行了一个多小时，蒂姆?库克(Tim Cook)已经耐心地回答了苹果进军电视市场的计划和他如何看待谷歌眼镜(Google Glass)等各类问题。但当一位参会听众就苹果各环保项目（比如其太阳能数据中心）的盈利能力向这位首席执行官发难的时候，库克发怒了。
So too would be concluding the EU’s own (re)negotiation of its existing trade agreement with Mexico. And there is a good chance Brussels could beat Donald Trump to the finish line on a deal with Mexico.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Total net profit for China’s commercial banks grew by 2.4 per cent last year, according to data from China’s bank regulator. Smaller banks saw increases in profit growth, while bigger banks slowed down.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Unlike most boy-band dudes going solo, he never sounds like he's sweating to get taken seriously – he never loses touch with the exuberance and swagger he brought to One Direction in the first place. So get used to this man – you'll be hearing a lot more from him.
A modular microarray imaging system for highly specific COVID-19 antibody testing
The former Miss Israel, Gal Gadot spot 6th in the list of 10 most beautiful women of 2015. She is the leading fashion model for the clothing company Castro. Gadot is known for her role as Gisele Yashar in The Fast and the Furious film series.
2. You've suddenly become a Twitter thought leader。
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Yet for all Russia's pretence about a rebalancing of priorities towards Asia, since the fallout over Ukraine, it still measures itself against the West, and America in particular.
Fast & Furious 6 helped place two other actors high on our list: Vin Diesel and the late Paul Walker. Diesel lands in fourth place with $887 million. Fast & Furious 6 earned $789 million at the box office worldwide. The third movie in his Riddick franchise hit theaters just a few months after. It only pulled in $98 million, but that was enough to put Diesel ahead of his co-star Walker on our list.
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
STEP 4: REMIND EVERYONE about what an "idiot" or "moron" they are
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Succeeding as an entrepreneur takes hard work and persistence because, unfortunately, there is no business-startup fairy who magically bestows success on small businesses and their owners.
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
虽然仿生腿对截肢者来说是巨大的福音，但是它们与人体缺乏真正的神经联系，导致依靠仿生腿走路十分麻烦和劳累。但是去年，西雅图的居民Zac Vawter 安装了世界上第一支思想控制的腿，一种直接接受从他大脑发出信号的仿生肢体。
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Actively expanding China's opening up to the world
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
But with the US close to full employment and inflation moving up towards the target, “you can see how tighter policy would be warranted,” he says. “It wouldn’t take a whole lot to shift the equation.”
艾玛·汤普森曾因影片《霍华德庄园》(Howards End)以及《理智与情感》(Sense and Sensibility)两次获得奥斯卡金像奖，而她把小金人放在洗手间这一做法也广为人知，她说：“放在其他地方都显得格格不入，它们太大了，又金光闪闪。”而艾玛并不是唯一一个这样做的人，苏珊·萨兰登（Susan Sarandon）、莱昂纳尔·里奇（Lionel Richie）以及肖恩·康纳利（Sean Connery）都称自己把小金人放在浴室等地方。
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
"He promised when he took office that he would have a Cabinet that was 50 percent women, and then he did it," Maddow said. "Would you make that same pledge?"
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
明年，寻找新楼盘的买家将会有更多的选择。根据科克伦阳光营销集团(Corcoran Sunshine Marketing Group)提供的数据，明年（2015年——译注）曼哈顿、布鲁克林和皇后区长岛市(Long Island City)新上市的共管公寓预计将增加一倍以上，从2014年的3444套增加到8366套。
Having earned a living for the last four years while her contemporaries go to school every day, she has been forced to mature quickly.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
It will be interesting to see which direction they go at the trade deadline. They have a handful of solid players along with Brook Lopez.
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
Copestake said fears over economic austerity and the stability of the euro had pushed the index of euro zone cities down in the past year while the inclusion of Caracas was due to artificially high exchange rate controls.
Auto sales: Car sales reach 17 million but manufacturers scramble to adjust capacity as trucks and SUVs soar in popularity. Pressure to hold down corporate fuel averages drives margins on small cars far below break-even.
Length-scale dependence of protein hydration-shell density
2.German: 22.2 percent increase
Best Companies rank: 1
Paris is in third place with 18.03 million forecast visitors.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
In a sign that civil service jobs may be losing their appeal, a report issued by recruitment website Zhaopin in late March said more than 10,000 public sector employees, including civil servants and staff members at public institutions, had submitted their resumes to potential employers through the site in just two months. The number was 34 percent higher during the same period last year, the report said.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Wheel skates look somewhat like regular inline skates, except that the wheels are much larger, up to the size of bicycle tires. They are seen as a cross between an inline skate, a ski, and a bike. Recently, a company called Chariot Skates said they had come up with something unique—the Chariot wheel skates. According to the company, wheel skates are "revolutionary new skating products." Revolutionary? They do at least revolve. New? No. The first wheel skate was made more than 142 years ago.
The reading is just below economists' forecasts but it's not altogether surprising. When the People's Bank of China unexpectedly cut interest rates last month, some analysts said the move was likely a pre-emptive one and that a spate of weak data was likely ahead. Well, here it is.
About this collection
On the flip side, why do so many JetBlue flights arrive late during the holidays (22 percent)? For one thing, it flies to and from some of the busiest airports in the country, including New York’s JFK, LaGuardia and Newark Airports. And it encounters some of the same issues as Hawaiian does over the Pacific.